According to "Howe's Historical Collection of Ohio" by Henry Howe, he was one of the first settlers in Champaign County. The History of Champaign County says he came to Ohio in 1799. He settled on the Mad River, in what later became Champaign County. When Urbana was later laid out, he moved to town and started a pottery. He also engaged in the mercantile business, was quite active in local politics, and served as one of the early sheriffs of the county, from 1821 to 1825 and 1833 to 1847. He was listed as an Elector for Champaign County, 8 Oct 1811; no. 22 in a list of 87 voters. He was also elected Treasurer of the County from 1840 to 1847. He and and his first wife, Jennie, had nine children, but only four have been found.

In Chancery Records for Champaign Co. Vol. 1, there are 11 references to Frederick Ambrose. No other Ambrose is named. The early references are to service on the grand or petit jury. In 1833 Frederick Ambrose was appointed guardian ad litem for the Hanback children [pg. 78]; and for the Taylor children [pg. 80]; also for Lung children [pg 92]. Frederick Ambrose admin. of Alexander Allen vs. Sally Allen et al. Has to do with selling of a lot owned by Alexander Allen. In 1838 Frederick Ambrose admin. of Wm. Winsor deceased v. Hannah Weldon et al. Again, having to do with lot in Urbana.

p. 425.
Frederick Ambrose 200010-01010

p. 052.
Ambrose, Frederic 2020001000000-1001101000000

Urbana, next household to Barbara McCOMSY
F. Ambrose 0101100100000-1101001000000

• Married: 27 MAY 1806 in Champaign County, Ohio
• Note: By John Thomas MG. Champaign Co., Ohio Marriages 1805-1820. ^{10 6 11}

1. Jacob AMBROSE b: ABT 1807
2. Peter AMBROSE b: ABT 1810
3. Newton AMBROSE b: 6 JUN 1819 in Urbana, Champaign County, Ohio
4. Margaret J. AMBROSE b: 5 MAR 1824

• Married: 27 JAN 1825 in Warren County, Ohio
• Note: License #2260. ^{6 12}

1. Gatch AMBROSE b: ABT 1826
2. Elizabeth AMBROSE b: 1827
3. James Roe AMBROSE b: 20 APR 1832 in Champaign County, Ohio
4. John AMBROSE b: ABT 1832 in Champaign County, Ohio
5. Susan AMBROSE b: ABT 1839 in Champaign County, Ohio
6. Rebecca Rachel AMBROSE b: ABT 1842

1. Title: Ruth Ambrose Stennett, AMBROSE, KAPP, and branch lines dating from their 1770s immigrations to 1990 (Oregon: Self, 1990)
2. Title: Judge Evan P. Middleton, History of Champaign County, Ohio, Vol. II, pp 150-152 (Indianapolis, Indiana: B. F. Bowen & Company, Inc., 1917)
3. Title: Carol Tillman
4. Title: Anita Fiedler
   Page: email 11 May 2000
5. Title: Church of Latter Day Saints, International Genealogical Index (www.familysearch.org)
   Page: Film #1903600 - abt 1776
6. Title: James Veregge , Descendants of Caleb Ambrose (Las Palma, CA, 15 Aug 1999)
7. Title: U.S. Federal Census (Provo, UT: Ancestry.com [images online],)
   Page: 1820OHM33_86P425A Image 236.
8. Title: U.S. Federal Census (Provo, UT: Ancestry.com [images online],)
   Page: 1830OHM19_128-0108
9. Title: U.S. Federal Census (Provo, UT: Ancestry.com [images online],)
   Page: 1840OHM704_382-0175
10. Title: Church of Latter Day Saints, International Genealogical Index (www.familysearch.org)
    Page: Batch #8717607, Sheet 41
11. Title: Anita Fiedler
    Page: Champaign County, Ohio Marriages 1805-1820, p3
12. Title: Miami Valley Genealogical Index (http://www.pcdl.lib.oh.us/miami/index.htm)